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Publications

PubMed

 

  1. Babakhani, K, Kucinskas, AL, Ye, X, Giles, ED, Sun, Y. Aging immunity: unraveling the complex nexus of diet, gut microbiome, and immune function. Immunometabolism (Cobham). 2025;7 (2):e00061. doi: 10.1097/IN9.0000000000000061. PubMed PMID:40352822 PubMed Central PMC12063687.
  2. Giles, ED, Cook, KL, Jenschke, RM, Corleto, KA, Landrock, D, Mahmood, TN et al.. Metabolic and transcriptional effects of bazedoxifene/conjugated estrogens in a model of obesity-associated breast cancer risk. JCI Insight. 2025;10 (8):. doi: 10.1172/jci.insight.182694. PubMed PMID:40048260 PubMed Central PMC12016928.
  3. Corleto, KA, Schedin, P, Kotta, AS, Strandmo, JL, Foster, SM, Lammoglia, N et al.. Targeting the menopause transition with metformin improves breast cancer outcomes, but discontinuation has deleterious effects on metabolic health: Findings from a preclinical model of postmenopausal breast cancer. bioRxiv. 2024; :. doi: 10.1101/2024.11.25.625083. PubMed PMID:39651199 PubMed Central PMC11623501.
  4. Noh, JY, Han, HW, Kim, DM, Giles, ED, Farnell, YZ, Wright, GA et al.. Innate immunity in peripheral tissues is differentially impaired under normal and endotoxic conditions in aging. Front Immunol. 2024;15 :1357444. doi: 10.3389/fimmu.2024.1357444. PubMed PMID:39221237 PubMed Central PMC11361940.
  5. Jospe, MR, Liao, Y, Giles, ED, Hudson, BI, Slingerland, JM, Schembre, SM et al.. A low-glucose eating pattern is associated with improvements in glycemic variability among women at risk for postmenopausal breast cancer: an exploratory analysis. Front Nutr. 2024;11 :1301427. doi: 10.3389/fnut.2024.1301427. PubMed PMID:38660060 PubMed Central PMC11039850.
  6. Corleto, KA, Strandmo, JL, Giles, ED. Metformin and Breast Cancer: Current Findings and Future Perspectives from Preclinical and Clinical Studies. Pharmaceuticals (Basel). 2024;17 (3):. doi: 10.3390/ph17030396. PubMed PMID:38543182 PubMed Central PMC10974219.
  7. Giles, ED, Purcell, SA, Olson, J, Vrieling, A, Hirko, KA, Woodruff, K et al.. Trends in Diet and Cancer Research: A Bibliometric and Visualization Analysis. Cancers (Basel). 2023;15 (15):. doi: 10.3390/cancers15153761. PubMed PMID:37568578 PubMed Central PMC10417030.
  8. Sanchez, L, Epps, J, Wall, S, McQueen, C, Pearson, SJ, Scribner, K et al.. SIM2s directed Parkin-mediated mitophagy promotes mammary epithelial cell differentiation. Cell Death Differ. 2023;30 (6):1472-1487. doi: 10.1038/s41418-023-01146-9. PubMed PMID:36966227 PubMed Central PMC10244402.
  9. Wellberg, EA, Corleto, KA, Checkley, LA, Jindal, S, Johnson, G, Higgins, JA et al.. Preventing ovariectomy-induced weight gain decreases tumor burden in rodent models of obesity and postmenopausal breast cancer. Breast Cancer Res. 2022;24 (1):42. doi: 10.1186/s13058-022-01535-x. PubMed PMID:35725493 PubMed Central PMC9208221.
  10. Kotta, AS, Kelling, AS, Corleto, KA, Sun, Y, Giles, ED. Ghrelin and Cancer: Examining the Roles of the Ghrelin Axis in Tumor Growth and Progression. Biomolecules. 2022;12 (4):. doi: 10.3390/biom12040483. PubMed PMID:35454071 PubMed Central PMC9032665.
  11. Baine, RE, Johnston, DT, Strain, MM, Henwood, MK, Davis, JA, Reynolds, JA et al.. Noxious Stimulation Induces Acute Hemorrhage and Impairs Long-Term Recovery after Spinal Cord Injury (SCI) in Female Rats: Evidence Estrous Cycle May Have a Modulatory Effect. Neurotrauma Rep. 2022;3 (1):70-86. doi: 10.1089/neur.2021.0055. PubMed PMID:35112109 PubMed Central PMC8804264.
  12. Schembre, SM, Jospe, MR, Giles, ED, Sears, DD, Liao, Y, Basen-Engquist, KM et al.. A Low-Glucose Eating Pattern Improves Biomarkers of Postmenopausal Breast Cancer Risk: An Exploratory Secondary Analysis of a Randomized Feasibility Trial. Nutrients. 2021;13 (12):. doi: 10.3390/nu13124508. PubMed PMID:34960058 PubMed Central PMC8707938.
  13. Fabian, CJ, Klemp, JR, Marchello, NJ, Vidoni, ED, Sullivan, DK, Nydegger, JL et al.. Rapid Escalation of High-Volume Exercise during Caloric Restriction; Change in Visceral Adipose Tissue and Adipocytokines in Obese Sedentary Breast Cancer Survivors. Cancers (Basel). 2021;13 (19):. doi: 10.3390/cancers13194871. PubMed PMID:34638355 PubMed Central PMC8508448.
  14. Glenny, EM, Coleman, MF, Giles, ED, Wellberg, EA, Hursting, SD. Designing Relevant Preclinical Rodent Models for Studying Links Between Nutrition, Obesity, Metabolism, and Cancer. Annu Rev Nutr. 2021;41 :253-282. doi: 10.1146/annurev-nutr-120420-032437. PubMed PMID:34357792 PubMed Central PMC8900211.
  15. Fabian, CJ, Befort, CA, Phillips, TA, Nydegger, JL, Kreutzjans, AL, Powers, KR et al.. Change in Blood and Benign Breast Biomarkers in Women Undergoing a Weight-Loss Intervention Randomized to High-Dose ω-3 Fatty Acids versus Placebo. Cancer Prev Res (Phila). 2021;14 (9):893-904. doi: 10.1158/1940-6207.CAPR-20-0656. PubMed PMID:34244155 PubMed Central PMC8416797.
  16. Giles, ED, Wellberg, EA. Preclinical Models to Study Obesity and Breast Cancer in Females: Considerations, Caveats, and Tools. J Mammary Gland Biol Neoplasia. 2020;25 (4):237-253. doi: 10.1007/s10911-020-09463-2. PubMed PMID:33146844 PubMed Central PMC8197449.
  17. Giles, ED, Brown, IL, MacLean, PS, Pan, Z, Melanson, EL, Heard, KJ et al.. The In Vivo Net Energy Content of Resistant Starch and Its Effect on Macronutrient Oxidation in Healthy Adults. Nutrients. 2019;11 (10):. doi: 10.3390/nu11102484. PubMed PMID:31623184 PubMed Central PMC6835355.
  18. Presby, DM, Checkley, LA, Jackman, MR, Higgins, JA, Jones, KL, Giles, ED et al.. Regular exercise potentiates energetically expensive hepatic de novo lipogenesis during early weight regain. Am J Physiol Regul Integr Comp Physiol. 2019;317 (5):R684-R695. doi: 10.1152/ajpregu.00074.2019. PubMed PMID:31553623 PubMed Central PMC6879845.
  19. Sherk, VD, Jackman, MR, Higgins, JA, Giles, ED, Foright, RM, Presby, DM et al.. Impact of Exercise and Activity on Weight Regain and Musculoskeletal Health Post-Ovariectomy. Med Sci Sports Exerc. 2019;51 (12):2465-2473. doi: 10.1249/MSS.0000000000002082. PubMed PMID:31274683 PubMed Central PMC7194137.
  20. Giles, ED, Jindal, S, Wellberg, EA, Schedin, T, Anderson, SM, Thor, AD et al.. Metformin inhibits stromal aromatase expression and tumor progression in a rodent model of postmenopausal breast cancer. Breast Cancer Res. 2018;20 (1):50. doi: 10.1186/s13058-018-0974-2. PubMed PMID:29898754 PubMed Central PMC6000949.
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